{"id":29976,"date":"2017-05-07T15:52:57","date_gmt":"2017-05-07T15:52:57","guid":{"rendered":"https:\/\/inhalio.com\/?p=29976"},"modified":"2017-05-07T15:52:57","modified_gmt":"2017-05-07T15:52:57","slug":"keith-kelsens-the-scent-narrative-scentual-healing-scent-based-medicine","status":"publish","type":"post","link":"https:\/\/inhalio.com\/china\/2017\/05\/07\/keith-kelsens-the-scent-narrative-scentual-healing-scent-based-medicine\/","title":{"rendered":"Keith Kelsen\u2019s The Scent Narrative: SCENTUAL HEALING: Scent-based Medicine"},"content":{"rendered":"

Recent discoveries have proven that scent receptors are not limited to the nose!\u00a0 Recently, Dr. Hans Hatt and his team have found almost all human tissues have some of the olfactory receptors in large quantities.[1]<\/a>\u00a0 \u00a0<\/sup><\/p>\n

There are huge implications from this finding.\u00a0 The sense of smell has long been ignored as a primary scent, but research in the field has been growing at an exponential rate.\u00a0 Scientists who paid attention to under researched olfactory receptors, won a Nobel Peace Prize for \u201cDemystifying the Sense of Smell<\/u><\/em>.\u201d <\/em>Now, there are important learnings as to what this sense is and how it works. Scent has long been acknowledged as being tied to memory; it now is being tied to self-healing.\u00a0 The first mention of the category, Scent-based Medicine<\/em> was in the New York Times in an article titled Smell Turns Up in Unexpected Places<\/u><\/em>[2]<\/a>. <\/em>\u00a0It revealed that \u201cscent has different healing properties than previously thought\u201d and first reported that scent receptors were not limited to the nose.<\/p>\n

Dr. Hanns Hatt and his team of biologists has found, \u201cMore than 15<\/strong> of the olfactory receptors that exist in the nose are also found in human skin cells<\/strong>.\u00a0 I\u2019ve been arguing for the importance of these receptors for years,\u201d said Dr. Hatt, who calls himself the<\/em> Ambassador of smell<\/em>, \u201cIt was a hard fight.\u201d 2 Dr. Hatt has been a professor at the Faculty of Biology and owner of the chair for cell physiology at the\u00a0Ruhr-University Bochum<\/a>, where the study was done.\u00a0 He was the first to recognize that olfactory receptors also play an important role in cells outside the nose.\u00a0 The whole concept of scent receptors outside the nose seems alien, almost like science fiction.<\/p>\n

It is, however, scientific fact that our odor receptors are among the most ancient chemical sensors in the body.\u00a0 Scent is finally coming of age as a critically important sense. Research is quickening on the validation of scent and its impact on health.\u00a0 Many are calling it Scent-based Medicine<\/em> as an alternative to traditional pharmacology.<\/p>\n

\u201cOver the last decade or so, scientists have discovered that odor receptors are not solely confined to the nose, but found throughout body,\u201d said Dr. Hatt, \u201cin the liver, the heart, the kidneys and even sperm, where they play a pivotal role in a host of physiological functions.2\u201d These discoveries pave the way for exciting new developments in scent, especially in healthcare. Dr. Hatt found there was a physiological response to exposing these receptors (named OR2AT4) to an odor known as Sandalore, a base note with a Sandalwood amyris woody type. \u00a0In a series of human tests, skin abrasions healed 30% faster after exposure to Sandalore.\u00a0 A powerful diffusive that imparts a rich, warm, natural sandalwood character apparently creates molecular signals to induce healing of injured tissue. Scientists think this could lead to new products for aging skin and recovery treatments after skin trauma.<\/p>\n

\u201cIf you think of olfactory receptors as specialized chemical detectors, instead of as receptors in your nose that detect smell, then it makes a lot of sense for them to be in other places,\u201d said professor of physiology at Johns Hopkins University, Jennifer Pluznick, who found that olfactory receptors help control metabolic function and regulate blood pressure\u00a0in the kidneys of mice. [3]<\/a><\/p>\n

Dr. Hatt and his team have identified olfactory receptors in several other organs, including the liver, heart, lungs, colon and brain. In fact, there\u2019s genetic evidence suggesting that nearly every organ in the body contains olfactory receptors. \u00a0This highly important sense can detect a multitude of compounds. \u00a0The capacity of the olfactory system to distinguish among a huge universe of chemical compounds depends on the encoding in the mammalian genome.<\/p>\n

The odor information gathered is funneled through a single common signaling pathway. Researchers wondered whether this signaling pathway might be exploited to detect and respond to changes in the chemical composition of the kidney\u2019s \u201cinternal environment\u201d. Olfactory receptors are known to play chemosensory roles outside of the olfactory epithelium, most notably in sperm[4]<\/a>, although research continues other bodily functions, like the kidneys.<\/p>\n

The kidney is an an ideal organ in which the capabilities of the olfactory chemosensory machinery could be brought to bear. The possibility of scent lowering blood pressure, reducing kidney stones or improving kidney health in humans is astounding. The kidney must keep careful track of the chemical composition of the tubular fluid as it moves through the different segments of the nephron. \u00a0For example, scent may be beneficial to the kidney to adjust its filtration, reabsorption, or secretion rates in response to changes in metabolite levels, as well as to promote clearance of substances or dicarboxylic acids, to avoid renal stone formation. \u00a0In their study, they examined whether olfactory-like signaling plays a role in the kidney by assaying for the presence of proteins necessary for olfactory signaling in the kidney, and by assaying renal function in mice lacking a protein necessary for olfaction. That may play a critical role physiologically in regulating fundamental aspects of renal function. In conclusion, they have uncovered the presence of the olfactory signaling system in the kidney, demonstrated its specific localization and are researching how scent can positively affect its function.<\/p>\n

Scent has impact on procreation as well.\u00a0 Long held as an aphrodisiac, now scent has a more practical implication.\u00a0 Dr. Hatt was one of the first scientists to study these functions in detail. In a study published in 2003, he and his colleagues reported that olfactory receptors\u00a0found inside the testes<\/a>\u00a0function as a kind of chemical guidance system that enables sperm cells to find their way toward an unfertilized egg, giving new meaning to the notion of sexual chemistry[5]<\/a>. They identified, cloned, and functionally expressed a previously undescribed human testicular. In human\u00a0sperm<\/a>,\u00a0the receptor for synthetic lily of the valley was detected and shown\u00a0its activation leads to a positive chemotactic<\/a>\u00a0reaction of the human sperm<\/a>\u00a0and accelerates its rate. \u00a0Dr. Hatt has shown in his lab the important functions of other olfactory receptors in both the sperm of men and over 20 fragrances in\u00a0vaginal secretions<\/a> by women.\u00a0 Taken together, the results indicated that human sperm chemotaxis may be a critical component of the fertilization process.\u00a0 This can be an indicator for new research to deal with infertility.<\/p>\n

Prostate cancer is among the leading killer of men and scent may have a solution.\u00a0 According to the U.S. Centers for Disease Control and Prevention (CDC) the leading causes of cancer death in men are lung cancer, prostate cancer and colorectal cancer. Dr. Hatt and his team also reported that exposing olfactory receptors in the human prostate to beta-ionone, a primary odor compound in violets and roses, appeared to inhibit the spread of prostate cancer<\/strong> cells\u00a0by switching off errant genes[6]<\/a>.<\/p>\n

While preventing prostate cancer may not be possible, early detection does save lives.\u00a0 For example, early detection can offer many cures including aromatherapy with a high potential for therapy in clinical application.\u00a0The laboratory of Dr. Hatt also intensively studies the effect of\u00a0essential oils<\/a>\u00a0and spices on the\u00a0trigeminal nerve<\/a> channels and other areas of the body. \u00a0 His\u00a0laboratory<\/a>\u00a0demonstrated<\/a>\u00a0that\u00a0aromatherapy<\/a>\u00a0and its molecular mechanisms of action can be explained by the modulation of brain receptors through the use of perfumes<\/a>.<\/p>\n

Athletic recovery and combating the aging process for muscles could also be impacted by scent.\u00a0 Grace Pavlath, biologist at Emory University, published a study on olfactory receptors in skeletal muscles. She found that bathing the receptors in Lyral, a synthetic fragrance of Lily of the Valley,\u00a0promoted the regeneration of muscle tissue. Blocking these receptors by neutralizing the genes, was found to inhibit muscular regeneration. This suggested that odor receptors are a necessary component of the intricate biochemical signaling system that causes stem cells to morph into muscles cells and replace damaged tissue.2 No doubt, few scientists ever imagined that fragrance would possess any significant medical benefits.[1] \u00a0\u201cThis was totally unexpected,\u201d Dr. Pavlath said. \u201cWhen we were doing this, the idea that olfactory receptors were involved in tissue repair was not out there.\u201d<\/p>\n

The history of scent and the $43 Billion industry it has become is more than just a pleasant accessory. Olfactory receptors are the largest subset of G-protein-coupled receptors (GPRCs), a family of proteins found on the surface of cells, that allow the cells to sense what is going on around them. These receptors are a common target for drugs,\u00a040% of all prescription drugs reach cells via GPCRs<\/a>, offering a huge opportunity for what might be called scent-based medicine<\/strong>.<\/p>\n

Due to the slow rate of adaptation in the Medical Industry, resistance to any \u201cdisruption\u201d, the aversion to new things that are not pharma based, the true unexplored complexity of the olfactory system and the politics around \u201cself-healing\u201d, this opportunity will require time. Despite the recent advances, scientists so far have matched few of these receptors to the specific chemical compounds they react to.<\/p>\n

Today, we can expand our understanding and think of olfactory receptors as a \u201clock-and-key system\u201d, with an odor molecule as the key to the receptor\u2019s lock. Only certain molecules fit with certain receptors. When the right molecule comes along and alights on the matching receptor, it sets in motion an elaborate choreography of biochemical reactions. Inside the nose, this culminates in a nerve signal being sent to the brain, which we perceive as odor. Today we know that the same apparatus can fulfill other biological functions as well. Welcome to the world of Scent-based Medicine!<\/p>\n

Keith Kelsen<\/strong>
\nCEO and Founder Inhalio – Contact<\/a><\/p>\n

\n

[1]<\/a> H. Hatt, G. Gisselmann, etal:\u00a0Expression profile of ectopic olfactory receptors determined by deep sequencing.<\/em><\/strong>\u00a0In:\u00a0PLOS ONE<\/em><\/a>.<\/em>\u00a08(2), 2013, Art. Nr. e55368.<\/p>\n

[2]<\/a> Smell Turns Up in Unexpected Places<\/strong>, October 14, 2014, on Page D3 of the\u00a0New York edition:\u00a0Order Reprints<\/a><\/p>\n

[3]<\/a> \u00a0vol. 106 no. 6 Jennifer L. Pluznick,\u00a0etal\u00a02059\u20132064,\u00a0doi: 10.1073\/pnas.0812859106 Functional expression of the olfactory signaling system in the kidney<\/strong><\/p>\n

[4]<\/sup><\/a> Spehr\u00a0M,\u00a0et al.(2003)\u00a0Identification of a testicular odorant receptor mediating human sperm<\/strong>\u00a0Abstract\/FREE\u00a0Full Text<\/a><\/p>\n

[5]<\/a> Identification of a testicular odorant receptor mediating human sperm chemotaxis: <\/strong>US National Library of Medicine<\/a> National Institutes of Health<\/a> Science<\/u>: <\/u>2003 Mar 28 \u00a0Hatt H<\/a>., <\/strong>Spehr M<\/a>1<\/sup>,\u00a0Gisselmann G<\/a>,\u00a0Poplawski A<\/a>,\u00a0Riffell JA<\/a>,\u00a0Wetzel CH<\/a>,\u00a0Zimmer RK<\/a><\/p>\n

[6]<\/a> Activation of an olfactory receptor inhibits proliferation of prostate cancer cells.<\/strong> In:J Biol Chem.<\/a>\u00a02009 Jun 12. Epub 2009 Apr 23, Neuhaus EM<\/a> ,\u00a0Hatt H<\/a>., etal:.<\/p>\n","protected":false},"excerpt":{"rendered":"

Recent discoveries have p … <\/p>\n

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